Douglas B. Matthews

Department of Psychology

The University of Memphis

Memphis, TN 38152

(901) 678-5461

doug-matthews@mail.psyc.memphis.edu

Education | Professional Memberships | Professional Experience

Grants | Honors | Publications | Presentations | Invited Colloquia

Education

• M.A. Student, Christian Apologetics, Biola University

• Postdoctoral Research Fellow, University of North Carolina-Center for Alcohol Studies, 1999

Laboratory of Dr. A. Leslie Morrow

• Postdoctoral Research Associate, Miami University, 1996

Laboratory of Dr. Peter Simson

• Ph.D., Psychology, Miami University, 1996

Dr. Phillip J. Best , advisor

• M.A., Psychology, Miami University, 1994

• B.S., Psychology/Biology (cum laude), Southwest Missouri State University, 1991

Professional Memberships

American Psychological Society

Research Society on Alcoholism

Professional Experience

• Director, Tennessee Center for Addiction Research, 2003 - 2005

• Board of Directors, Tennessee Biotechnology Association, University of Memphis Representative, 2003 - present

• Associate Professor, Department of Psychology, The University of Memphis, 2003 - present

• Adjunct Assistant Professor, Anatomy and Neurobiology, University of Tennessee Health Science Center, 2003 - present

• Assistant Professor, Department of Psychology, The University of Memphis, 1999 - 2003

• Feinstone Center for Genomic Research, The University of Memphis, 2001 - present

• Postdoctoral Research Fellow (Lab Manager), University of North Carolina-Center for Alcohol Studies,     1996-1999

• Graduate Research Assistant, Miami University, Laboratory of Dr. Phillip J. Best, 1992-1996

• Graduate Teaching Assistant, Miami University, 1992-1995

• Graduate Teaching Assistant, University of Memphis, 1991-1992

• Undergraduate Tutor, Statistics, Southwest Missouri State University, 1989-1991

Grants

• National Institute on Alcohol Abuse and Alcoholism: National Research Service Award (1 F31 AA05414-01A1).

Prenatal Ethanol: Place Cell and Spatial Memory Effects.

Principal Investigator

$13,008.00 total cost

• National Institute on Alcohol Abuse and Alcoholism: National Research Service Award (1 F32-AA05519-01).

GABAergic Adaptations to Ethanol Self-administration.

Principal Investigator

$56,336.00 total cost

• Alcoholic Beverage Medical Research Foundation (06/01/00 - 05/30/02)

The neuroactive steroid 3a-hydroxy-5a-pregnan-20-one modulates ethanol-induced decreases in spatial cognitive processing.

Principal Investigator

$80,000.00 total cost

• University of Memphis Faculty Award (06/01/01 - 05/30/02)

Effects of the neuroactive steroid 3[a]-hydroxy-5[a]-pregnan-20-one on spatial cognitive processing in the rat.

Principal Investigator

$4,000.00 total cost

• University of Memphis Faculty Award (06/01/01 - 05/30/02)

Effects of de novo blockade of the neuroactive steroid 3[a]-hydroxy-5[a]-pregnan-20-one on ethanol induced spatial working memory impairments.

Principal Investigator

$4,000.00 total cost

• National Institute of Health (9/25/00 - 8/30/05) (1 U01 MH61971-01)

Targeted mutagenesis of the mouse genome and neural phenotype

Principal Investigator: Dan Goldwitz, UT-Memphis Medical Center

$12,774,513.00 total costs

Investigator and Co-Director of Alcohol Core

$1,277,515.00 Total cost to the University of Memphis

• National Institute on Alcoholism and Alcohol Abuse (02/01/02 - 1/31/07)

INIA: Systems Mechanism in Alcohol-Stress Interaction

Principal Investigator

$1,378,312.00 total cost

• University of Memphis Faculty Award (7/01/04 – 6/30/05)

The effect of ethanol consumption on physiology and gambling behavior: identifying mechanisms to encourage effective self-regulation.

Principal Investigator

$6,000.00 total cost

• National Institute on Alcoholism and Alcohol Abuse (9/18/04 – 9/17/07)

GABAa receptor g[2] knockout: ethanol and spatial memory.

Principal Investigator

$381,750.00 total cost

• National Institute on Alcoholism and Alcohol Abuse

Ethanol mechanisms in GABAAR gene targeted mice

Subcontract from U of Pittsburgh

PI on Subcontract

$278,456

Honors

•	T.W. Briggs Foundation Excellence in Teaching Award -- Nominated
•	External Reviewer Baylor University Department of Psychology and Neuroscience
•	Young Investigator Award - Research Society on Alcoholism, 2002.
•	Early Career Research Award, University of Memphis, 2001.
•	Junior Faculty Travel Award, American Society for Biochemistry and Molecular Biology Ethanol and Cell Signaling, Oct. 1999.
•	NIAAA Postdoctoral Fellowship (1 F32-AA05519-01), 1998-1999.
•	Neurobiology Training Grant Recipient, UNC-Chapel Hill, 1997-1998.
•	NIAAA Pre-doctoral Fellowship (1 F31 AA05414-01A1), 1996.
•	Dissertation Fellowship, Miami University, Psychology, 1995-1996.
•	Research Society on Alcoholism, Junior Investigator Award, June 1997.
•	Research Society on Alcoholism/International Society for Biomedical Research on Alcoholism, Graduate Student Travel Award, June 1996.
•	Jeff Stein Graduate Fellowship, $1,000.00, May 1994.
•	Achievement Awards, Miami University, 5 awards totaling $1,250.00.
•	Abstract selected by the Committee on National Advocacy of the Research Society on Alcoholism for distribution to national news services and media representatives.
•	Capretta Memorial Scholarship for Outstanding Graduate Student in Psychology, April 1996.
•	Letters of Commendation, Miami Psychology Department, 1993, 1994, 1995, 1996.
•	Participant, Society for Neuroscience Press Conference on the Adolescent Brain, 2003.

Publications

    Matthews, D.B., & Best, P.J. (1995). Fimbria/fornix lesions facilitate the learning of a non-spatial response task. Psychonomic Bulletin & Review, 2(1), 113-116.

   Matthews, D.B., Simson, P.E., & Best, P.J. (1995). Acute ethanol impairs the use of spatial memory but not the use of stimulus/response memory in the rat. Alcoholism: Clinical and Experimental Research, 19(4), 902-909.

   Matthews, D.B., Simson, P.E., & Best, P.J. (1995). Impaired spatial memory in rats after acute ethanol exposure. Alcoholism: Clinical and Experimental Research, 19(4), Highlights.

   Matthews, D.B., Simson, P.E., & Best, P.J. (1996). Ethanol alters the spatial processing of hippocampal place cells: a mechanism for impaired navigation when intoxicated. Alcoholism: Clinical and Experimental Research, 20(2), 404-407.

   Matthews, D.B., Best, P.J., White, A.M., Vandergriff, J., & Simson, P.E., (1996). Ethanol impairs spatial cognitive processing: new behavioral and electrophysiological findings. Current Directions in Psychological Science, 5(4), 111-115.

   Matthews, D.B., & Best, P.J. (1997). Evidence for the flexible use of spatial knowledge in the rat. Psychobiology, 25(4), 294-302.

   Matthews, D.B., Devaud, L.L., Fritschy, J.M., Sieghart, W., & Morrow, A.L. (1998). Differential regulation of GABAA receptor gene expression by ethanol in the rat hippocampus vs. cerebral cortex. Journal of Neurochemistry, 70, 1160-1166.

   Matthews, D.B., & Simson, P.E. (1998). Prenatal exposure to ethanol disrupts spatial memory: effect of the training-testing delay period. Physiology & Behavior, 64(1), 63-67.

   Grobin, A.C., Matthews, D.B., Devaud, L.L., & Morrow, AL (1998). The role of GABAA receptors in the acute and chronic effects of ethanol. Psychopharmacology, 139(1/2), 2-19.

   Matthews, D.B., & Uhler-Dietz, B. (1998). The black sheep effect: how positive and negative advertisements affect voters' perceptions of the sponsor of the advertisement. Journal of Applied Social Psychology, 28, 1902-1914.

   Matthews, D.B., Illgen, M.A., White, A.M., & Best, P.J. (1999). Acute ethanol administration impairs spatial performance while facilitating non-spatial performance in rats. Neurobiology of Learning and Memory, 72, 169-179.

   Davaud, L. L., Matthews, D. B., & Morrow, A. L. (1999). Gender impacts behavioral and neurochemical adaptations in ethanol dependent rats. Pharmacology, Biochemistry & Behavior, 64, 841-849.

   Morrow, A.L., Janis, G.L., Van Doren, M.J., Matthews, D.B., Samson, H.H., Janis, P., & Grant, K.A. (1999). Neurosteroids mediate pharmacological effects of ethanol: A new mechanism of ethanol action? Alcoholism: Clinical and Experimental Research, 23, 1933-1940.

   VanDoren, M.J., Matthews, D.B., Janis, G.C., Grobin, A.C., Devaud, L.L., & Morrow, A.L. (2000). Neuroactive steroid 3a-hydroxy-5a-Pregnan-20-one modulates behavioral and electrophysiological actions of ethanol. Journal of Neuroscience, 20, 1982-1989.

   Matthews, D.B., & Morrow, A.L. (2000). The effects of acute and chronic ethanol exposure on spatial cognitive processing and hippocampal function in the rat. Hippocampus, 10, 122-130.

   White, A.M., Matthews, D.B., & Best, P.J. (2000). Ethanol, memory and hippocampal function: A review of recent findings. Hippocampus, 10, 88-93.

   Matthews, D.B. (2000). Ethanol and the hippocampal system: behavior to molecular biology. Hippocampus, 10, 87.

   Matthews, D.B, Kralic, J. E., Devaud, L.L., Fritschy, J.M., & Morrow, A.L. (2000). Chronic blockade of N-methyl-D-aspartate receptors alters g-Aminobutyric acid type A receptor gene expression and function in the rat. Journal of Neurochemistry, 74, 1522-1528.

   Kampov-Polevoy, A.B, Matthews, D.B., Gause, L., Morrow, A.L., & Overstreet, D.H. (2000). Development of physical dependence upon alcohol in p rats: changes in seizure thresholds, anxiety and patterns of alcohol drinking. Alcoholism: Clinical and Experimental Research, 24, 278-284.

   Matthews D.B., Criswell, H.E., Grobin, A.C., & Morrow, A.L. (2000). Chronic ethanol consumption alters recovery of spontaneously active medial septal/diagonal band of Broca neurons from GABA-microiontophoresis. Alcoholism: Clinical and Experimental Research, 24, 1427-1432.    

   Matthews, D.B., Overstreet, D.H., Rezvani, A.H., Devaud, L.L. & Morrow, A.L. (2001). Comparisons of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels. Pharmacology, Biochemistry & Behavior, 68, 13-21.

   Grobin, A.C., Matthews, D.B., Montoya, D., Wilson, W.A., Morrow, A.L., & Swartzwelder, H. S. (2001). Age related differences in neurosteroid potentiation of muscimol-stimulated ³⁶Cl- flux following chronic ethanol treatment. Neuroscience, 105, 547-552.

   Hoffman, S.E., & Matthews, D.B. (2001). Ethanol-induced impairments in spatial working memory are not due to deficits in learning. Alcoholism: Clinical and Experimental Research, 25, 856-861.   

   Morrow, A.L., VanDoren M.J., Penland, S.N. & Matthews, D.B. (2001). The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Research Reviews, 37, 98-109.

    Matthews, D.B., Morrow, A.L., Tokunaga, S. & McDaniel, J.R.  (2002).  Acute ethanol administration and acute allopregnanolone administration impair spatial memory in the Morris water task. Alcoholism:  Clinical and Experimental Research. 26, 1747-1751.

   Tokunage, S., McDaniel, J.R., Morrow, A.L. & Matthews, D.B. (2003). Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity. Brain Research, 967, 273-280.

   Mittleman, G. Van Drunt, C.L. & Matthews D.B. (2003). Schedule induced ethanol self-administration in DBA/2J and C57BL/6J. Alcoholism: Clinical and Experimental Research, 27, 918-925.

   Morrow, A.L., Khisti, R., Tokunaga, S., McDaniel J.R. & Matthews, D.B. (2003). GABAergic neuroactive steroids modulate selective ethanol actions: Mechanisms and Significance. Neurosteroid Effects in the Central NervousSystem: The Role of the GABAA Receptor, Smith, S.H. (Ed.) CRC Press LLC, Miami, pp. 219-245.

   Silvers, J.M., Tokanaga, S., Mittleman, G. & Matthews D.B. (2003). Chronic intermittent ethanol exposure during adolescence produces metabolic, hypnotic and cognitive tolerance in rats. Alcoholism: Clinical and Experimental Research. 27, 1606-1612. Highlighted article in issue

   The Complex Trait Consortium (CTC)* Lorraine Flaherty, Oduola Abiola, Joe M. Angel, Philip Avner, Alexander A. Bachmanov, John K. Belknap, Beth Bennett, Elizabeth P. Blankenhorn, David A. Blizard, Valerie Bolivar, Gudrun A. Brockmann, Kari J. Buck , Jean-Francois Bureau, William L. Casley, Elissa J. Chesler, James M. Cheverud, Gary A. Churchill, Melloni Cook, John C. Crabbe, Wim E. Crusio Ariel Darvasi, Gerald de Haan Peter Demant, R.W. Doerge, Rosemary W. Elliott, Charles R. Farber, Jonathan Flint, Howard Gershenfeld, John P. Gibson, Weikuan Gu, Heinz Himmelbauer, Robert Hitzemann, Hui-Chen Hsu, Kent Hunter, Fuad Iraqi, Ritsert C. Jansen, Thomas E. Johnson, Byron C. Jones, Gerd Kempermann, Frank Lammert, Lu Lu, Kenneth F. Manly, Douglas B. Matthews, Juan F. Medrano, Margarete Mehrabian, Guy Mittleman, Beverly A. Mock, Jeffrey S. Mogi, Xavier Montagutelli, Grant Morahan, John D. Mountz , Hiroki Nagase, Richard S. Nowakowski, Bruce F. O'Hara, Alexander V. Osadchuk, Beverly Paigen, Abraham A. Palmer, Jeremy L Peirce, Daniel Pomp, Michael Rosemann, Glenn D. Rosen, Leonard C. Schalkwyk, Ze'ev Seltzer, Stephen Settle, Kazuhiro Shimomura, Siming Shou, James M. Sikela, Linda D. Siracusa, Jimmy L. Spearow, Cory Teuscher, David W. Threadgill, Linda A. Toth, Ayo A. Toye, Csaba Vadasz, Gary Van Zant Edward, Wakeland, Robert W. Williams, Huang-Ge Zhang, Fei Zou (2003). The nature and identification of quantitative trait loci: a community’s view. Nature Genetics Reviews, 4, 911-915.

   Silvers, J. M., Tokunaga, S., Berry, R.B., White, A.M. & Matthews D.B. (2003). Impairments in spatial learning and memory: ethanol, allopregnanolone and the hippocampus. Brain Research Review. 967, 273-280.

   Berry, R.B. & Matthews, D.B. (2004). Acute ethanol administration selectively impairs spatial memory in C57BL/6J Mice. Alcohol, 32, 9-18.

   Khisti, R.T., VanDoren, M.J., Matthews, D. B. & Morrow A.L. (2004). Ethanol-induced elevation of 3a-hydroxy-5a-pregnan-20-one does not modulate motor in-coordination in rats. Alcoholism: Clinical and Experimental Research, 28, 1249-1256.

   Matthews, D.B. & Silvers, J.R. (2004). The use of acute ethanol administration as a tool to investigate multiple memory systems. Neurobiology of Learning and Memory. 82, 299-308. Invited Review.

   The Complex Trait Consortium (2004) Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpaa MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics, 36, 1133-1137.

   Matthews, D.B. (2004). Neuroactive steroids and ethanol-induced decreases in spatial cognitive processing. Proceedings of the 31st International Medical Advisory Group Conference, 31, 85-90.

   Kralic, J.E., Criswell, H.E., Osterman, J., O’Buckley, T.K., Matthews, D.B., Hamre, K., Breese, G.R., Homanics, G.E. & Morrow, A.L. (2005). Genetic essential tremor in GABAA a1 subunit knockout mice. Journal of Clinical Investigation, 115, 774-779.

   Matthews, D.B., Bhave, S.V., Belknap, J.K., Brittingham, C., Chesler, E.J., Hitzemann, R.J., Hoffmann, P.L., Lu, L., McWeeney, S., Miles, M.F., Tabakoff, B. & Williams, R.W. (in press). Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research.

Presentations

   Renner, M.J., Matthews, D.B., & Pierre, P.J. Factors influencing object investigation in rats: a cumulative analysis. Presentation at the Psychonomic Society, November 1992.

   Best, P.J., & Matthews, D.B. Acute ethanol alters hippocampal "place cells". Presentation at the 6th annual Midwestern Hippocampal Conference, June 1994.

   Best, P.J., Simson, P.E., & Matthews, D.B. Acute ethanol alters hippocampal place cells. Presentation at the "Effects of Acute Ethanol on Brain Limbic Mechanisms", Symposium at the annual Research Society on Alcoholism, June 1995.

   Matthews, D.B., & Dietz-Uhler, B. The effects of political advertisements on political-group identity. Presentation at the "Current Applications of Social Identity Theory" symposium, Eastern Psychological Association, March 1996.

   Best, P.J., Matthews, D.B., & Simson, P. E. Brain mechanisms of alcohol induced spatial cognitive deficits. Invited paper. Midwestern Psychological Association, May 1996.

   Matthews, D.B. Spatial learning and septal electrophysiology. Fetal Alcohol Research Group, June 1996.

   Matthews, D.B. Effect of ethanol on spatial cognitive processing. Presentation at the "Ethanol and the hippocampal system: Behavior to molecular biology" symposium at the annual American Psychological Society meeting, May 1998. (Symposia organizer).

   Matthews, D.B. Neurosteriods contribute to electrophysiological effects of ethanol in the medial septal nucleus. Presentation at the "Neurosteriods mediate pharmacological effects of ethanol: A new mechanism of ethanol action?" symposium at the annual Research Society on Alcoholism, June 1999.

   Matthews, D.B., Van Doren, M.J., & Morrow, A.L. Ethanol inhibition of medial septal/diagonal band of Broca spontaneous neural activity is modulated by allopregnanolone. Ethanol and Cell Signaling symposium, American Society for Biochemistry and Molecular Biology.

   Matthews, D.B. Ethanol impairs cognitive processing. Symposium at the annual Research Society on Alcoholism, June, 2000. (Symposia organizer and chair).

   Matthews, D.B. Neurosteroids mimic and may contribute to effects of ethanol on cognitive performance in rats. Ethanol Sensitivity of GABAA Receptors In Vitro and In Vivo, Research Society on Alcoholism Poster Discussion, June, 2001.

   Matthews, D.B. Development of a high throughput ethanol screen to test mice with single base pair mutations. Presentation at the ³Use of Genetic and Neurobiological Screens for Understanding the Basis of Alcoholism² symposium at the annual Research Society on Alcoholism, June, 2001.

   Matthews, D.B. Impairments in spatial cognitive processing: Ethanol, allopregnanolone and the hippocampus. Symposium at the European Behavioural Pharmacology Society and European Brain and Behaviour Society, September, 2001.

   Matthews D.B., Tokunaga, S., Silvers, J.M. & Morrow A.L. Steroid neurogenesis is critical for ethanol induced cognitive impairments to moderate ethanol doses. Symposium at the International Behavioral Neuroscience Meeting, April 2003.

   Matthews, D.B. Steroidogenesis is critical for spatial memory impairments produced by moderate doses of ethanol. Research Society on Alcoholism, 2003. Plenary Lecture.

   Matthews, D.B. (2003).Neuroactive steroids and ethanol-induced decreases in spatial cognitive processing. 31st International Medical Advisory Group, October, 2003.

   Matthews, D.B., Lu, L., Chesler, E.J. & Williams, R.W. (2004).Use of WEBqtl to identify QTLs associated with footshock stress and ethanol related behaviors. Symposium at the Research Society on Alcoholism, June, 2004. (Symposia co-organizer).

   Matthews, D.B., Chesler, E., Williams, R.W., Hamre K & Goldowitz G. (2005). High-throughput screening for ethanol phenotypes. Symposium at the Research Society on Alcoholism, June, 2005.

   Matthews, D.B., Silvers, J.M., Tokunaga, S. & Morrow, A.L. (2005). Binge alcohol exposure during adolescence produces behavioral, electrophysiological and biochemical adaptations in hippocampus. Symposium and platform presentation at the Neurobehavioral Teratology Society, June, 2005.